The great initiative to “promote the building of a community with a shared future for mankind” is an immense project that involves multiple areas of human society and is vital to the future direction of mankind. It reveals to us that the future of mankind is deeply interconnected. It also allows us to see that in the field of human immunotechnology and healthcare development, it is likewise necessary to start building a community with a shared future for human immune health.

The recent global COVID-19 pandemic was a huge lesson for all of mankind. It made us recognize that the fundamental way for each of us to safeguard our own health is by boosting the human body’s immunity. Relevant organizations, institutions, and scientists from all over the world must join forces to constantly expand international communication, deepen mutual cooperation, and start constructing an immunological barrier for mankind. This is the only way to safeguard our collective health and future.

Science and technology are the tools of human progress. Sharing scientific and technological achievements is inevitable as mankind looks to the future. The experience and lessons of history tell us that, faced with a global public health crisis and widespread disease, human society must unite in solidarity in order to achieve ultimate victory.

To this end, we jointly issue this declaration:

We will establish a coordinated management system for human immune health and integrate resources to collectively build a healthy human immune system project. Grounded in the present with a future-oriented vision, we will establish long-term prevention and treatment systems and solutions to respond to global public health crises and human immune health issues that may arise again in the future.

1. Collectively build a “coordinated management system for human immune health”

This system will primarily integrate the resources of relevant organizations, institutions, and scientists, enabling timely communication and coordination regarding several emergent issues that may arise in international public health crises. 

Main tasks:

(1) Coordinate prevention and management: communicate, organize, and share experience in a timely manner to avoid wrong turns, make up for lost time, and minimize damage.

(2) Unify action and resource allocation: join forces and work together to achieve precise targeting, minimize damage, and avoid escalation of the crisis.

(3) Connect scientists in related fields: discuss, research, and tackle different issues that occur in the crisis in a timely manner, and quickly convert results to applications so as to save time and share resources.

2. Collectively build a “healthy human immune system project”

From a future-oriented perspective, if mankind wishes to ensure a decisive victory in the fight against disease, we must boost our overall immunity; this is the fundamental solution. To this end, the long-term task for coordinated management is:

To collectively build a “healthy human immune system project” that promotes and safeguards the establishment and implementation of 3 immunoscience systems for healthy human “mental immunity, nutritional immunity, and behavioral immunity”. 

Science has already proven that 80% of human diseases are caused by immune system issues and solutions to nearly 100% of health problems depend on strong immunity. The fundamental way to overcome diseases and public health crises lies in boosting the human body’s immunity.

We believe that the promotion of this project not only has enormous significance for unexpected public health crises, but also has the same significance for chronic human diseases and suboptimal health conditions, which are constantly worsening. This is an endeavor that can yield immediate benefits and requires long-term effort.

(1) Gather talent from all sides to establish a scientific framework for a healthy human immune system project that primarily consists of “mental immunity, nutritional immunity, and behavioral immunity” with the goal of creating new lifestyles for human immune health, pushing healthy human lifestyles to a higher level.

“Mental immunity, nutritional immunity, and behavioral immunity” mostly involve things that can be done at no cost or relatively cheaply. The focus will be on generalizing and summarizing a set of “mental immunity and behavioral immunity” parenting and exercise tutorials that are simple, scientific, and easy to put into action. At the same time, in accordance with the features of different regions and ethnic groups, a set of scientific recipes and nutritional intervention plans for immune health that promote “nutritional immunity” will be introduced. 

(2) Use national, social, and professional forces at multiple levels to drive the construction and implementation of the “healthy human immune system project”. After organizing necessary training, call upon various allied members, from campuses to neighborhoods and from local regions to society as a whole, to mobilize and take action to create an outstanding environment for human immune health. 

(3) Mobilize scientists in relevant fields to join together and intensify research on “superantigens”, as well as the integrative development of modern biotechnology, traditional Chinese medicine, and western medicine. This will inject new momentum and vitality into the enhancement of human immunity, the fight against public health crises, and the resolution of people’s health issues.

Superantigens are the most powerful immunity-boosting substance currently known to mankind. Their ability to activate immunity is 2000-50000 times that of other typical antigens like ginseng, cordyceps, and reishi mushroom. Renowned as “masters of immunity”, they have enormous significance for mankind’s response to public health crises and other diseases. However, at present, mankind’s ability to develop and use them is extremely limited; only China’s Xiehe superantigens have obtained a national drug approval number. These superantigens have been used in the prevention and control of Ebola, SARS, AIDS, and the COVID-19 virus with remarkable effectiveness. Moreover, they have no side effects and have been hailed as “all-purpose vaccines”. 

Rolf Martin Zinkernagel, professor of experimental immunology at the University of Zurich and Nobel Prize winner, once asserted: “The emergence of Xiehe superantigens is equivalent to the discovery of penicillin!”

Chen Tingzuo, one of China’s leading biomedical authorities and founder of superantigens, has also said: “With a firm theoretical foundation and clear support from clinical data, China’s Xiehe superantigens are definitely rock-solid!”

As innovation and development continues in superantigen science, it is certain to lead mankind into a new era of immunotechnology. Further development and utilization of superantigens is the collective responsibility of mankind in solving public health crises and human health problems. We all agree that our alliance must first incorporate superantigens into relevant scientists’ collaborative research topics. We believe that superantigen research results and applications, along with the integrative development of modern biotechnology, traditional Chinese medicine, and western medicine, are sure to shed new light on the construction of a community with a shared future for human immune health as well as other human immune health causes.

Institutional signers of the joint declaration

Chen Tingzuo International Immune Science Foundation, Western Returned Scholars Association Entrepreneur Alliance, The Lancet, Human Immune Health Alliance, United Nations Pacific Rim Institute for Development and Education, McGill University Health Centre in Canada, Beijing University of Chinese Medicine, The Chinese University of Hong Kong, Shenzhen University, China Immunity Engineering Technology Center, World Health Industries Union, China International Federation of Chinese Medicine Industries, World Institute for Self-Healing, World Superantigen Application Research Center, World Friends Day Health Forum, Xiehe Biology Group, New England Journal of Traditional Chinese Medicine.

Individual signers of the joint declar

Xu Changdong (president of the Western Returned Scholars Association Entrepreneur Alliance), Zhang Boli (academician of the Chinese Academy of Engineering), Barry Barish (Nobel Prize laureate), Chen Juyu (chairman of Xiehe Biology Group), Ferid Murad (Nobel Prize laureate), Rolf Martin Zinkernagel (Nobel Prize laureate), Thomas C. Südhof (Nobel Prize laureate), Carol W. Greider (Nobel Prize laureate), Edvard Moser (Nobel Prize laureate), Randy W. Schekman (Nobel Prize laureate), Richard Horton (editor-in-chief of The Lancet), Mohamad Sawan (fellow of the Canadian Academy of Engineering), Shiu Cho Tak (fellow of the Royal College of Physicians of Edinburgh), Zhao Nanming (academician of the International Eurasian Academy of Sciences), Li Gang (fellow of the Orthopedic Research Society), Zhang Xueji (fellow of the American Institute for Medical and Biological Engineering), Li Kang (general and vice-president of Army Medical University), Dong Baowei (general and cancer expert of Chinese PLA General Hospital), Lu Yao (postdoctoral fellow), Wang Bin (professor), Xiao Hongjun (professor), Yuan Shaoping (professor), Wu Shaohua (professor), Li Diangui (National Master of TCM), Zhang Jingtao (chairman of World Friends Day Organizing Committee), Chen Yan (secretary-general of South China University of Technology Alumni Association)